The SERVAL project, led by MRCG at LSHTM in partnership with the , introduced the R21/Matrix-M malaria vaccine across 15 villages in URR. With over 3,500 people vaccinated, including children as young as five months, the village of Sotuma Sainey Kandeh recorded zero malaria cases last year, for the first time in decades.
"Before, malaria was everywhere,” said Bala Kandeh, a farmer. “Now, I can farm without worrying about getting sick or taking any member of my family to the health centre. Life is easier.”
Like many, Bala was hesitant at first. Rumours about side effects made people nervous. But local health workers, like Mama Kandeh, took the time to go door-to-door, answering questions and building trust. “Now, people can see the results,” he said. “They believe.”
A pregnant woman shared how she took the vaccine with no challenges: “I didn’t get sick. I didn’t get malaria and now I have a healthy baby. I tell others not to be afraid.” Over time, persistent engagement and positive testimonials like these helped change perceptions.
The village head, Alagie Kandeh, noted how the vaccine changed healthcare in their area. “We haven't had malaria patients needing hospital care this year, unlike before, when we were constantly taking patients to the hospital”, said Alagie. “Initially, some were unsure about the vaccine, but now everyone has seen its benefits, and we are grateful to MRCG for their free diagnosis, medication, and emergency support.”
Even those who did not take the vaccine are seeing its impact. Alieu Mballow, a young resident, admits he regrets not joining the first round. “Next time, I will be the first in line, and because I can see the impact of the vaccine especially on our children.”
This community-wide shift is part of a regional initiative. The SERVAL study is also running in Burkina Faso, covering 24 villages. Its primary aim is to assess whether seasonal mass vaccination with R21 can significantly reduce malaria prevalence and support elimination efforts. As Dr. Annette Erhart, one of the lead researchers, explains, “We aim to protect entire communities, monitor the vaccine’s safety, and reduce malaria to the point of elimination.”
Regional leaders, including the URR Governor, Samba Bah, are hopeful: “This is the kind of research that transforms our health system and supports our national development goals.”
As the rainy season approaches, the SERVAL team is gearing up to give booster doses and reach those who missed out last year with the ultimate goal - Keep malaria away for good.
According to the , Africa accounted for 94% of global malaria cases and 95% of deaths in 2023, with children under 5 years making up 76% of the fatalities. Overall, there were 263 million cases and 597,000 deaths worldwide that year.
In The Gambia, the burden of malaria varies by region, with the Upper River Region (URR) experiencing the highest rates, especially during the rainy season. For instance, studies by et al, from 2012 to 2015, showed malaria prevalence in URR villages ranged from 4.32% to 36.75%. While the burden has decreased substantially over the last 10-20 years, malaria transmission is still ongoing.
For Sotuma Sainey Kandeh and beyond, this vaccine trial isn’t just a study, it is a turning point. Through science, community trust, and support, the village can hope for a malaria-free future which now feels closer than ever.
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