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Dr Richard Wall

Assistant Professor

°®ÍþÄÌapp of Hygiene & Tropical Medicine
Keppel Street
London
WC1E 7HT
United Kingdom

Richard leads the TB Drug Discovery Group at LSHTM, an interdisciplinary team including experts in target deconvolution, genetic manipulation, zebrafish infection models and metabolomics. Our group supports the development of new treatments for tuberculosis (TB), investigates the mode of action of novel compounds and explores the underlying biology of emerging therapeutic targets.

 

Richard completed his PhD at the University of Nottingham (2012) before joining Prof Rita Tewari’s group, where he studied parasite motility and cell division in the malaria model Plasmodium berghei. He then moved to the University of Dundee (2015) to work with Dr Susan Wyllie on mode of action studies for antiparasitic compounds. There, he used a combination of genetic, proteomic, and bioinformatic tools to identify drug targets for diseases including Chagas’ disease, Leishmaniasis, Sleeping Sickness, and Malaria.

 

He now applies many of these same skills and methodologies to TB research. After joining the lab of Prof Anil Koul at LSHTM (2022), he began contributing to early-stage TB drug discovery, in close collaboration with our industrial partner, and now leads the programme. His group's goal is to advance the development of shorter, safer, and more effective treatments for TB by identifying new drug targets and supporting the progression of promising compounds.

Affiliations

Department of Infection Biology
Faculty of Infectious and Tropical Diseases

°®ÍþÄÌapp

TB Centre
Antimicrobial Resistance Centre

Teaching

Richard regularly supervises lab-based summer project students and is a personal tutor for the MSc Medical Microbiology course. He is also co-module organiser for the Novel Drug Discovery & AMR (3169) MSc module, where he leads lab practicals and the group tutorials.

Research

Richard's primary research objective is driving various TB drug discovery projects in close collaboration with our industry partner. His other interests include using saturation mutagenesis to identify resistance-conferring mutations, the impact of target overexpression in drug resistance and drug target deconvolution of phenotypic hit compounds.
Research Area
Bacteriology
Genetics
Microbiology
Molecular biology
Parasitology
Drug discovery and development
Disease and Health Conditions
Tuberculosis
Chagas disease
Leishmaniasis
African trypanosomiasis
Malaria

Selected Publications

Lamprecht, DA; WALL, RJ; Leemans, A; Truebody, B; Sprangers, J; Fiogbe, P; Davies, C; Wetzel, J; Daems, S; PEARSON, W; Pillay, V; Saylock, S; Ricketts, MD; Davis, E; Huff, A; Grell, T; Lin, S; Gerber, M; Vos, A; Dallow, J; WILLCOCKS, SJ; Roubert, C; Sans, S; Desorme, A; Chappat, N; ... KOUL, A.
2025
Nature
Pérez, CA; Lenaerts, A; Villellas, C; Guillemont, J; Dallow, J; Painter, H; Ammerman, N; Hassan, A; Golovkine, G; Brock, L; Chauffour, A; Aubry, A; Mai, T; Wong, S; CLARK, T; Nam, K; Kim, J; Choi, J; Crabbe, M; Esqui, J; Lounis, N; Stoops, B; Amssoms, K; Bartolome-Nebreda, J; Gruppo, V; ... Lamprecht, D.
2024
Research Square
PHELAN, J; Van den Heede, K; Masyn, S; Verbeeck, R; CLARK, TG; Lamprecht, DA; KOUL, A; WALL, RJ;
2024
Scientific reports
Trenaman, A; Tinti, M; WALL, RJ; Horn, D;
2024
Nature communications
Lamprecht, D; WALL, R; Davies, C; Pearson, W; Davis, E; Willcocks, S; Dallow, J; Leemans, A; Wetzel, J; Daems, S; Sancheti, P; Monshouwer, M; Aguilar-Pérez, C; Koul, A; Sprangers, J; Fiogbe, P; Saylock, S; Ricketts, M; Huff, A; Grell, T; Draghia-Akli, R; Lin, S; Gerber, M; Dhar, N; Vos, A; ... Jackson, P.
2024
Research Square
WALL, RJ; MacGowan, SA; Hallyburton, I; Syed, AJ; Ajay Castro, S; Dey, G; Milne, R; Patterson, S; PHELAN, J; Wiedemar, N; Wyllie, S;
2024
mBio
Tulloch, LB; Tinti, M; WALL, RJ; Weidt, SK; Corpas-Lopez, V; Dey, G; Smith, TK; Fairlamb, AH; Barrett, MP; Wyllie, S;
2024
PLoS pathogens
Zhang, N; Samad, A; Zahedifard, F; WALL, R; Horn, D; Zoltner, M; Field, M;
2024
bioRxiv
Braillard, S; Keenan, M; Breese, KJ; Heppell, J; Abbott, M; Islam, R; Shackleford, DM; Katneni, K; Crighton, E; Chen, G; Patil, R; Lee, G; White, KL; Carvalho, S; WALL, RJ; Chemi, G; Zuccotto, F; González, S; Marco, M; Deakyne, J; Standing, D; Brunori, G; Lyon, JJ; Castañeda-Casado, P; Camino, I; ... Chatelain, E.
2023
Science translational medicine
González, S; WALL, RJ; Thomas, J; Braillard, S; Brunori, G; Camino Díaz, I; Cantizani, J; Carvalho, S; Castañeda Casado, P; Chatelain, E; Cotillo, I; Fiandor, JM; FRANCISCO, AF; Grimsditch, D; Keenan, M; KELLY, JM; Kessler, A; Luise, C; Lyon, JJ; MacLean, L; Marco, M; Martin, JJ; Martinez Martinez, MS; Paterson, C; Read, KD; ... De Rycker, M.
2023
Science translational medicine