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Professor Stuart Pocock

Professor of Medical Statistics

United Kingdom

Stuart Pocock is Professor of Medical Statistics (since 1989) at the app of Hygiene and Tropical Medicine, a leading European centre of excellence for biostatistical research and teaching.

His primary research interest concerns clinical trials, both as regards methodological developments and applied collaboration in major trials, mainly in cardiology. He also has interests in observational epidemiology especially pharmaco-epidemiology. His particular methodological areas of expertise include: standards for the statistical reporting of trials and epidemiological studies, the statistical ethical and organisational principles for data monitoring including early stopping guidelines, the win ratio approach to a hierarchical composite of outcomes with clinical priorities, adaptive designs, handling non-proportional hazards, the value of repeat-event analyses, use and misuse of propensity scores, the pros and cons of non-inferiority trials, problems of multiplicity in trial reporting, eg, subgroup analyses, multiple outcomes and covariate adjustment, and the development/validation of prognostic risk scores.

Professor Pocock and his colleagues run a statistical centre for the design, conduct, analysis and reporting of major clinical trials, especially in cardiovascular diseases. He is also a consultant statistician for a wider range of clinical trials in which expert statistical advice is needed, and serves as a statistical member of many trial data monitoring and steering committees.

He collaborates internationally especially with the Centro Nacional de Investigaciones Cardiovasculares in Madrid, and the Cardiovascular Research Foundation and Mount Sinai School of Medicine in New York. He is a frequent lecturer on a variety of clinical trials issues, and has published over 600 articles in peer-reviewed journals, and a popular textbook “Clinical Trials: a Practical Approach”.

Affiliations

Department of Medical Statistics
Faculty of Epidemiology and Population Health

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Centre for Data and Statistical Science for Health

Teaching

Module in Clinical Trials every Autumn

Other MSc Medical Statistics activities

PhD student supervision

Mentor to Cardiology Fellows in Madrid

Lecturing to Cardiology Fellows in Mt Sinai, NY

Research

His primary research interest concerns clinical trials, both as regards methodological developments and applied collaboration in major trials, mainly in cardiology. He also has interests in observational epidemiology especially pharmaco-epidemiology. His particular methodological areas of expertise include: standards for the statistical reporting of trials and epidemiological studies, the statistical ethical and organisational principles for data monitoring including early stopping guidelines, the win ratio approach to a hierarchical composite of outcomes with clinical priorities, adaptive designs, handling non-proportional hazards, the value of repeat-event analyses, use and misuse of propensity scores, the pros and cons of non-inferiority trials, problems of multiplicity in trial reporting, eg, subgroup analyses, multiple outcomes and covariate adjustment, and the development/validation of prognostic risk scores.

Selected Publications

Castellano, JM; POCOCK, SJ; Bhatt, DL; Quesada, AJ; Owen, R; Fernandez-Ortiz, A; Sanchez, PL; Marin Ortuño, F; Vazquez Rodriguez, JM; Domingo-Fernández, A; Lozano, I; Roncaglioni, MC; Baviera, M; Foresta, A; Ojeda-Fernandez, L; Colivicchi, F; Di Fusco, SA; Doehner, W; Meyer, A; Schiele, F; Ecarnot, F; Linhart, A; Lubanda, J-C; Barczi, G; Merkely, B; ... SECURE Investigators,
2022
New England Journal of Medicine
Mahfoud, F; Kandzari, DE; Kario, K; Townsend, RR; Weber, MA; Schmieder, RE; Tsioufis, K; POCOCK, S; Dimitriadis, K; Choi, JW; East, C; D'Souza, R; Sharp, AS P; Ewen, S; Walton, A; Hopper, I; Brar, S; McKenna, P; Fahy, M; Böhm, M;
2022
Lancet (London, England)
Anker, SD; Butler, J; Filippatos, G; Ferreira, JP; Bocchi, E; Böhm, M; Brunner-La Rocca, H-P; Choi, D-J; Chopra, V; Chuquiure-Valenzuela, E; Giannetti, N; Gomez-Mesa, JE; Janssens, S; Januzzi, JL; Gonzalez-Juanatey, JR; Merkely, B; Nicholls, SJ; Perrone, SV; Piña, IL; Ponikowski, P; Senni, M; Sim, D; Spinar, J; Squire, I; Taddei, S; ... EMPEROR-Preserved Trial Investigators,
2021
The New England journal of medicine
POCOCK, SJ; Ferreira, JP; GREGSON, J; Anker, SD; Butler, J; Filippatos, G; Gollop, ND; Iwata, T; Brueckmann, M; Januzzi, JL; Voors, AA; Zannad, F; Packer, M;
2021
European heart journal
POCOCK, SJ; Rossello, X; Owen, R; COLLIER, TJ; Stone, GW; Rockhold, FW;
2021
Journal of the American College of Cardiology
Redfors, B; GREGSON, J; Crowley, A; McAndrew, T; Ben-Yehuda, O; Stone, GW; POCOCK, SJ;
2020
European heart journal
Gaziano, T; Castellano, JM; Dymond, A; Looby, A; Mealing, S; Owen, R; POCOCK, S; González-Juanatey, JR; Cordero, A; Fernández-Ortiz, A; Linhart, A; Schiele, F; Doehner, W; Fernández, LO; Fuster, V;
2025
The Lancet Regional Health - Europe
HAZEWINKEL, A-D; GREGSON, J; POCOCK, SJ; McMurray, J; Solomon, SD; Claggett, B; Packer, M; Anker, SD; Ferreira, JP; Docherty, K; Henderson, A; Jhund, P; Wilderäng, U; Wright, D;
2025
Journal of the American College of Cardiology
GREGSON, J; Taylor, D; Owen, R; COLLIER, T; J Cohen, D; POCOCK, S;
2025
Circulation
Kandzari, DE; Mahfoud, F; Townsend, RR; Kario, K; Weber, MA; Schmieder, RE; Tsioufis, K; POCOCK, S; Liu, M; DeBruin, V; Brar, S; Böhm, M;
2025
Circulation: Cardiovascular Interventions