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Dr David Lawrence

Clinical Research Physician

United Kingdom

Jump to: Affiliations Teaching Research Publications
My work spans multiple disciplines (clinical trials, epidemiology, diagnostics, health economics, anthropology) but is unified by an unwavering drive to reduce mortality and morbidity from advanced HIV disease.

I joined the Faculty of Infectious and Tropical Diseases in 2017 and was based in Gaborone, Botswana for four years where I worked as the Lead Clinician for the AMBIsome Therapy Induction OptimisatioN (AMBITION) trial. AMBITION was a phase III randomised controlled trial of a single, high-dose liposomal amphotericin regimen for HIV-associated cryptococcal meningitis and recruited patients from six sites across five countries in Southern Africa.

I returned to the UK in 2021 and following the success of the trial I am co-investigator on a number of research and non-research grants aimed at maximising the impact of the AMBITION regimen in routine care settings and applying research advances in cryptococcal meningitis to other HIV-associated fungal infections.

Alongside research I work two-days a week for the NHS as a HIV and Sexual Health doctor.

Affiliations
Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Teaching

I am module organiser of HIV 3174 which is an intensive face-to-face module taking place in Term 3. I lead the HIV component of the Diploma in Tropical Medicine and Hygiene and am a distance learning tutor on the IDM 501 HIV/AIDS module. I supervise research projects conducted by MSc students and I am currently supervising three PhD students. I have completed Module 1 and Module 2 of the Postgraduate Certificate in Learning and Teaching and am a Fellow of the Higher Education Academy.

Research
I am involved in a number of ongoing research projects including:

IMPRINT - an NIHR Global Health Research Group for HIV-associated fungal infections
SHARE-CM - an implementation project aimed at reducing mortality from cryptococcal meningitis in routine care
EFFECT - a clinical trial of combination anti-fungal therapy for cryptococcal antigenaemia
IMPALA - a clinical trial of injectable antiretroviral therapy for individuals with a history of challenges with adherence to oral treatment
Research Area
Clinical drug trials
Clinical trials
Diagnostics
Health economics
Medical anthropology
Anthropology
Implementation science
Disease and Health Conditions
HIV/AIDS
Sexually transmitted infections
Meningitis
Country
Botswana
Uganda
Malawi
Zimbabwe
South Africa
United Kingdom
Democratic Republic of the Congo
Mozambique
Guinea
Vietnam
Region
Sub-Saharan Africa (all income levels)

Selected Publications
Samuels, TH A; Molloy, SF; LAWRENCE, DS; Loyse, A; Kanyama, C; Heyderman, RS; Lai, WS; Mfinanga, S; Lesikari, S; Chanda, D; Kouanfack, C; Temfack, E; Lortholary, O; Hosseinipour, MC; Chan, AK; Meya, DB; Boulware, DR; Mwandumba, HC; Meintjes, G; Muzoora, C; Mosepele, M; Ndhlovu, CE; Youssouf, N; Harrison, TS; JARVIS, JN; ... Gupta, RK.
2025
The Lancet Global Health
Stott, KE; Tembo, D; Kajanga, C; Ahmadu, A; Namakhwa, D; Kolamunnage-Dona, R; Sarker, C; Moyo, M; Gondwe, E; Chimang’anga, W; Chasweka, M; Shah, RV; LAWRENCE, DS; Harrison, TS; JARVIS, JN; Lalloo, DG; Hope, W; Mwandumba, HC; Chimphambano, T; Dziwani, E; Kadzilimbile, A; Kateta, S; Kossam, E; Kukacha, C; Lipenga, B; ... Hafeez, S.
2025
Open Forum Infectious Diseases
BURKE, RM; Sabet, N; ELLIS, J; Rangaraj, A; LAWRENCE, DS; JARVIS, JN; FALCONER, J; Tugume, L; Bidwell, G; Berhanu, RH; MacPherson, P; Ford, N;
2025
The lancet. HIV
Ford, N; Rangaraj, A; JARVIS, JN; LAWRENCE, DS; Chou, R; Kamenshchikova, A; Hargreaves, S; BURKE, RM;
2025
Open forum infectious diseases
Ekusai-Sebatta, D; Namugenyi, RS; Laker, E; Mwaka, E; King, R; LAWRENCE, DS; SEELEY, J;
2025
International Health
LAWRENCE, D; JARVIS, J; Moyo, M; Jafali, J; Molloy, SF; Kumwenda, J; Kanyama, C; Hosseinipour, MC; Ndhlovu, CE; Mospele, M; Meya, DB; Rhein, J; Boulware, DR; Muzoora, C; Gupta, RK; Samuels, TH A; Youssouf, N; Chammard, T; Lortholary, O; Schutz, C; Meintjes, G; Mwandumba, HC; Harrison, TS; Jarvis, JN;
2025
Clinical infectious diseases
Tumusiime, V; RUZAGIRA, E; Norcross, C; Eshun-Wilsonova, I; Kitonsa, J; Bahemuka, UM; GRINT, D; Kimbugwe, G; Kakande, A; LAWRENCE, DS; Mwendia, F; Van Solinge, R; Van Eygen, V; Boateng, FA; CRESSWELL, F;
2025
°®ÍþÄÌapp of Hygiene & Tropical Medicine
Stott, KE; Mohabir, JT; Bowers, K; Tenor, JL; Toffaletti, DL; Unsworth, J; Jimenez-Valverde, A; Ahmadu, A; Moyo, M; Gondwe, E; Chimang'anga, W; Chasweka, M; LAWRENCE, DS; JARVIS, JN; Harrison, T; Hope, W; Lalloo, DG; Mwandumba, HC; Perfect, JR; Cuomo, CA; AMBITION Study Group,;
2024
mBio
Gakuru, J; Kagimu, E; Dai, B; Okurut, S; Nsangi, L; Bahr, NC; Okirwoth, M; Namuju, OC; JARVIS, JN; LAWRENCE, DS; Ahimbisibwe, C; ELLIS, J; Tadeo, KK; Boulware, DR; Meya, DB; Tugume, L;
2024
Clinical Infectious Diseases
Samuels, TH A; Molloy, SF; LAWRENCE, DS; Loyse, A; Kanyama, C; Heyderman, RS; Lai, WS; Mfinanga, S; Lesikari, S; Chanda, D; Kouanfack, C; Temfack, E; Lortholary, O; Hosseinipour, MC; Chan, AK; Meya, DB; Boulware, DR; Mwandumba, HC; Meintjes, G; Muzoora, C; Mosepele, M; Ndhlovu, CE; Youssouf, N; Harrison, TS; JARVIS, JN; ... Gupta, RK.
2024
medRxiv
David Lawrence

Contact

United Kingdom