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Professor Christian Bottomley

Professor in Medical Statistics

United Kingdom

I joined the International Statistics and Epidemiology Group at LSHTM in 2008. Prior to joining LSHTM, I completed a PhD in mathematical biology at University College London (UCL) and worked as a medical statistician in the Department of Primary Care and Population Sciences, also at UCL.

Affiliations

Department of Infectious Disease Epidemiology and International Health
Faculty of Epidemiology and Population Health

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Centre for Data and Statistical Science for Health
Centre for Evaluation
TB Centre
Antimicrobial Resistance Centre

Teaching

I am a course organiser for the module Design and Analysis of Epidemiological Studies, and also a tutor on the Epidemiology MSc and Clinical Trials MSc.

Research

I am statistician and infectious disease epidemiologist. My research centres around the evaluation of vaccines and other public health interventions aimed at reducing the burden of infectious disease among children in low-and-middle-income countries. I am also interested in the development of statistical methods, particularly around the analysis of time series data for evaluating population-level interventions.

I collaborate with researchers at various institutions, including the MRC Gambia, the KEMRI-Wellcome Trust Research Programme in Kenya, and more recently, the Biomedical Research and Training Institute (BRTI) in Zimbabwe.

Recently completed studies for which I was the principal statistician include:

• PregnAnZI-2: A trial evaluating the effectiveness of azithromycin, administered during labour, for preventing sepsis in newborns in The Gambia
• A trial of fractional doses of pneumococcal vaccines in Kenya

Ongoing studies for which I am the principal statistician include:

• IMPRESS: a cluster-randomised trial of a hospital management intervention in Malawi
• FIEBRE: a multi-country study investigating the causes of fever in children and adults
• SAVIS: a phase 1 trial of a vaccine against non-typhoidal Salmonella
• An evaluation of RajPusht - a complex intervention centred around a cash transfer programme for pregnant women in Rajasthan, India

Selected Publications

BOTTOMLEY, C; Kamau, A; Awori, JO; Driscoll, AJ; Park, DE; Sow, SO; Tapia, MD; Kotloff, KL; Ebruke, BE; ANTONIO, M; Howie, SR C; HAYES, RJ; SCOTT, JA G;
2025
International journal of epidemiology
GALLAGHER, KE; Lucinde, R; BOTTOMLEY, C; Kaniu, M; Suaad, B; Mutahi, M; Mwalekwa, L; Ragab, S; Twi-Yeboah, L; Berkley, JA; Hamaluba, M; Karani, A; Shangala, J; OTIENDE, M; Gardiner, E; Mugo, D; SMITH, PG; Tabu, C; Were, F; Goldblatt, D; SCOTT, JA G;
2024
The New England journal of medicine
ROCA, A; CAMARA, B; Bognini, JD; Nakakana, UN; Somé, AM; Beloum, N; Rouamba, T; Sillah, F; Danso, M; Jones, JC; Graves, S; Jagne, I; Getanda, P; DARBOE, S; Tahita, MC; Ndure, E; Franck, HS; Edmond, SY; Dondeh, BL; Nassa, WG J; Garba, Z; BOJANG, A; Njie, Y; BOTTOMLEY, C; Tinto, H; ... PregnAnZI-2 Working Group,
2023
JAMA
BOTTOMLEY, C; OOKO, M; GASPARRINI, A; KEOGH, RH;
2023
Statistics in medicine
BOTTOMLEY, C; OTIENDE, M; Uyoga, S; GALLAGHER, K; Kagucia, EW; Etyang, AO; Mugo, D; Gitonga, J; Karanja, H; Nyagwange, J; ADETIFA, IM O; AGWEYU, A; Nokes, DJ; Warimwe, GM; SCOTT, JA G;
2021
Nature communications
BOTTOMLEY, C; SCOTT, JA G; Isham, V;
2019
Epidemiologic Methods
Silaba, M; OOKO, M; BOTTOMLEY, C; Sande, J; Benamore, R; Park, K; Ignas, J; Maitland, K; Mturi, N; Makumi, A; OTIENDE, M; Kagwanja, S; Safari, S; Ochola, V; Bwanaali, T; Bauni, E; Gleeson, F; Deloria Knoll, M; ADETIFA, I; Marsh, K; Williams, TN; Kamau, T; Sharif, S; Levine, OS; Hammitt, LL; ... SCOTT, JA G.
2019
The Lancet Global Health
MARKS, M; Mitjà, O; BOTTOMLEY, C; Kwakye, C; Houinei, W; Bauri, M; Adwere, P; Abdulai, AA; Dua, F; Boateng, L; Wangi, J; Ohene, S-A; Wangnapi, R; Simpson, SV; Miag, H; Addo, KK; Basing, LA; Danavall, D; Chi, KH; Pillay, A; Ballard, R; Solomon, AW; Chen, CY; Bieb, SV; Adu-Sarkodie, Y; ... Study team,
2018
The Lancet Global health
TUSTING, LS; BOTTOMLEY, C; Gibson, H; KLEINSCHMIDT, I; Tatem, AJ; Lindsay, SW; Gething, PW;
2017
PLoS medicine
BOTTOMLEY, C; Isham, V; Vivas-Martínez, S; Kuesel, AC; Attah, SK; Opoku, NO; Lustigman, S; Walker, M; Basáñez, M-G;
2016
Parasites & vectors